Cytotoxic and trypanocidal activities of cinchona alkaloid derivatives

Cinchona Alkaloid

2-Phenylaminonaphthoquinones and related compounds: synthesis, trypanocidal and cytotoxic activities.

A series of new 2-aminonaphthoquinones and related compounds were synthesized and evaluated in vitro as trypanocidal and cytotoxic agents. Some tested compounds inhibited epimastigote growth and trypomastigote viability. Several compounds showed similar or higher activity and selectivity as compared with current trypanocidal drug, nifurtimox. Compound 4l exhibit higher selectivity than nifurtim...

Solution- and Solid-Phase Approaches in Asymmetric Phase-Transfer Catalysis by Cinchona Alkaloid Derivatives

Synthesis 2001, No. 11, 28 08 2001. Article Identifier: 1437-210X,E;2001,0,11,1742,1746,ftx,en;C03701SS.pdf. © Georg Thieme Verlag Stuttgart · New York ISSN 0039-7881 Abstract: The catalytic asymmetric alkylation under phase-transfer conditions of various substrates (enones, -fluoro ketones, glycineimines) promoted by chiral quaternary ammonium salts derived from cinchona alkaloids is described...

Synthesis of chiral chalcone derivatives catalyzed by the chiral cinchona alkaloid squaramide.

An effective method has been developed for the preparation of novel chiral chalcone derivatives under mild conditions from the easily accessible starting materials nitromethane and chalcone derivatives 2. The corresponding products were obtained in moderate yields with excellent enantioselectivities (up to 99%).

Melosuavines A-H, cytotoxic bisindole alkaloid derivatives from Melodinus suaveolens.

Eight new bisindole alkaloids, melosuavines A-C (1-3), having an aspidosperma-scandine linkage, melosuavines D-F (4-6), possessing an aspidosperma-aspidosperma skeleton, and melosuavines G and H (7 and 8) of the aspidosperma-venalatonine type, tenuicausine (9), and melodinine J (10) were isolated from the twigs and leaves of Melodinus suaveolens. The structures of 1-8 were elucidated by extensi...